The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eight V. paradoxa nutshells from seven sub-Saharan countries was compared, which were classified into three groups with chemometric method. Twenty-eight samples contained high total phenolic content, and exhibited moderate-higher antioxidant activity and strong α-glucosidase inhibitory activity. Furthermore, all fractions and isolated compounds were evaluated for their antioxidant and α-glucosidase inhibitory activities, and α-glucosidase inhibitory action mechanism of four characteristic constituents including protocatechuic acid, 3, 5, 7-trihydroxycoumarin, (2R, 3R)-(+)-taxifolin and quercetin was investigated via molecular docking method, which were all stabilized by hydrogen bonds with α-glucosidase. The study provided an effective approach to waste utilization of V. paradoxa nutshell, which would help to resolve waste environmental pollution and provide a basis for developing potential herbal resource for treating diabetes.
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DOI:
https://doi.org/10.1016/S1875-5364(19)30052-4Altmetric score:
Dimensions Citation Count:
Publication year
2019
Authors
Li, D.; Xiao, J.-Q.; Liu, W.-Y.; Zhang, C.-F.; Akihisa, T.; Abe, M.; Masters, E.-T.; Zhai, W.-W.; Feng, F.; Zhang, J.
Language
English
Keywords
medicinal plants
Geographic
Côte d'Ivoire, Ghana, Nigeria, Cameroon, Chad, Sudan, Uganda
