This session will explore the diverse biophysical and socio-economic interconnections that exist between the Amazon and its neighboring biomes, namely the Cerrado, Chiquitanía, Paramos and High Andes. It aims to identify the threats and tradeoffs deriving from pressures and interventions in these biomes, as well as potential solutions that could drive transformational change. Panelists will discuss the challenges associated to such connections and reflect on lessons steaming from successful experiences in Colombia, Brazil, Paraguay, Ecuador and Bolivia.